But yes, January, all those vitamin D deficiency is lower for sure. That's OK. Yeah, Zink's another one that's really, you know, important for immune function as well. So I tell you my story Zettl is it's like from Burchett's from the Bertsch plant we were just talking about. No, I like the few studies that I've seen and some people that I like doing insane juicing and they're already, like, messed up, you know, so I'm not concerned at all, like even like the oxalate. Yes. So like people like giving giving the vaccine people's immune response, some people can have that antibody dependent enhancement. Joe Rogan's ENTIRE episode with Dr. Rhonda Patrick broken into short audio clips for . Oh yeah. So there was it's like it was trending that acetate was better trending, meaning was non significant, although it was like forty percent versus twenty eight percent. Seventy percent of the people would get like symptoms ranging from fever, you know, cough and all the influenza, you know, flu symptoms. Because so many people fucked themselves up by trying to do things on their own and I did and now I'm scared. And then he would go without breathing for multiple seconds. But I think it was a month. Like when you take like a young population, as you get older, your immune system does decline. The only topic off limits is politics. And so, like those people are more likely to die from respiratory infections than people that don't have that, which it's a great way of kind of randomising people by their genes as opposed to doing a randomized controlled trial. And one of the first experiments I had that I was doing, like one of my first projects was. And I was like, this is amazing. I like love. It's like, OK, this is not my field. So that was like my my first Finnish sauna experience where it was like people are too open minded. And the fact that it does decrease the I don't know how it would affect an already formed cavity, but my cavities are gone. I know. I thought rocks were falling from the fucking sky and I couldn't watch the car. What about if you get active, if he exercises. We were doing a cleaning, you know, dental hygiene thing. It's been like just having having the effect. But you can go to Buffalo Trace website and take the virtual tour online. And what happens when you take I mean I mean, you can throw this on the you can flip flip this over and say, OK, what happens when you take the guy from the UK, the Brit, and put him in Australia, like without any sunscreen or without a hat or no answer? I mean, it was just I was thinking, God, if we didn't have this in the house and you couldn't go anywhere, luckily we have one here so I could use the one that's here. And I think people will become less scared as these as these therapeutics do emerge, which which which they will, I'm sure. And a good thing about that is that have you heard of antibody dependent enhancement? The other three that were asymptomatic had as they were, they were spreading sorry, shedding as much virus that could make them, you know, basically contagious and, you know, basically able to transmit the strains. So weird. There's like there's some kind of term where, like, women get like like what's that periodontitis or gingivitis. What about cold shock proteins and the I mean, how much difference is it between taking a really cold shower ice bath versus something like krail cryotherapy, like the place that I took you to. Like, I don't think that's odd. It's like, OK, this is this is this is like the morning and your circadian clock starts and then, you know, so you become sleepy when you're supposed to become sleepy, as long as you're not in tons of, you know, bright light at night. I haven't done. And, much of the conversation focused on the sunshine vitamin! I can't someone else. It was ever a sponsor of the podcast. Of course I'm nursing him. I've got two publications on it. So it's micrograms per liter in their blood. Right. Subscribe to our channels, COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More. And but, you know, there certain times of the year, depending on where you live and a more northern latitude where that UVB isn't even hitting the atmosphere. Vitamin D is different than vitamin C because it is fat-soluble and can be stored by the body. And can you take too much vitamin D? The study involved an investigation of supplementation using prophylactic vitamin D supplements. And that's the same. Sometimes you'll hear this EU receptor and that's how the virus gets in, it's like, I don't want that, I want less of that because that's how the virus gets in. I mean, I'm always trying to get them to have that. What's going to protect that area is muscle and strength and also flexibility work. Nootropics. And they're still winning. That's made by teeter. And so he had us do this thing where, like, everyone had to wake up. Yeah. And I swear I would I would have endurance just for sure. They beat each other with this these branches that are wet. I don't know. Glutathione Do you have a song in your house. I also had a gym I was going to for. Or two, because I've read a bunch of, you know, evidence surrounding this topic, you know, about all the other clinical evidence, all the genetic labs, all the animal like. I personally think taking the vitamin K and what's interesting about the vitamin K wine versus vitamin to without going into too much of a tangent is basically the the vitamin K one. And so but it totally fixed itself, thankfully. I miss our our soccer classes. Podcast Notes is a Signal From the Noise LLC Production, All Right Reserved, Berkshire Hathaway Annual Shareholders Meeting, Christopher Lockhead's Follow Your Different, Everyday Espionage Podcast with Andrew Bustamante, Feel Better, Live More With Dr. Rangan Chatterjee, Moonshots and Mindsets with Peter Diamandis, Network State Podcast with Balaji Srinivasan, Spearhead with Naval Ravikant and Babak Nivi, The Unraveling Podcast with Jocko Willink and Darryl Cooper, This Week in Startups with Jason Calacanis, Where It Happens with Sahil Bloom and Greg Isenberg, Sauna: if you have access use the sauna regularly to improve cardiovascular health and immune functions take a hot bath if you dont have access, Theres a big difference between oral vitamin C and Intravenous vitamin C, You can take vitamin C orally but will need a big dose and it still wont have the same effect; IV once per week if you can, Sleep plays a crucial role in immunity, homeostasis, and regulation of body functions, People are actively working on monoclonal antibodies, Improved therapeutic treatments coming, including more repurposing of drugs that will make things less scary, As you get older your immune system declines, There are lifestyle components of immune system you can be proactive about: exercise, sleep, supplements, nutrition, gut-microbiome health, Besides age, the major regulator of immune function seems to be previous virus exposure, not genetics, At any given point you have antibodies against 10 different viruses but youre not always getting sick, 50-80% of US population has had CMV and most people dont ever know they have had it and show no symptoms, CMV impacts immune function differently depending on when you get it, When youre young, it enhances immune response but for older people its deleterious, Interesting tie-in to COVID-19 because we know older people are more prone to severity, Its likely that theres some cross-immunity happening since SARS-COV-2 viruses is part of beta coronaviruses along with SARS-CoV-1 and MRSA, 15-30% of common colds come from coronaviruses so theres a good hypothesis that potentially one or two of common cold virus antibodies could interact with SARS-CoV-2 and neutralize it, Antibody binds to virus and instead of neutralizing it, changes the configuration so the virus can get into the cell better, This activates the immune system and causes pathology, This results in a higher viral load without antibodies to neutralize, Weve seen it happen with coronaviruses, including SARS-CoV-1 and MRSA, The spike region is where antibodies bind and is also the region the virus uses to get into the cell, Currently seeing two major strain mutations in the spike regions one mutation more prominent in Asia, one mutation more predominant in Europe and North America, Brings to light an interesting genetic link to mutations, Theres a theory that the mutation is causing peoples immune system to become more active and lead to severe COVID-19, Monoclonal antibodies: identify specific antibody that binds to spike protein and manufacture them, Problem is this will offer short lived protection since you are not making your own antibodies as you would with a vaccine, Continuous exploration into repurposing drugs and combination drug treatments, Anecdotally, the majority of people on ventilators die partly because ventilators cause more damage to the lungs and can induce more damage, But its hard to say which came first did the ventilator do the damage or was the damage so severe that the patient needed a ventilator, People with Type O blood seem to be less susceptible to contracting COVID-19, People with Type O blood create Type A antibodies which bind to spike region and neutralize antibody so it cant enter the cell, We saw this in SARS-CoV-1 so maybe same for SARS-CoV-2, Another (unproven) theory: Type O blood people have lower levels of blood factor involved in clotting, Hearing more stories that some prisoners are trying to contract SARS-CoV-2 to get out of jail by spitting in a cup and passing to others, First off, its important to distinguish between asymptomatic and pre-symptomatic, Some people do not have symptoms at the time of testing but develop symptoms later so are actually pre-symptomatic, Its possible that viruses have already gone around that environment so antibodies from those viruses are helping in immunity from SARS-CoV-2, Rhonda was also searching to literature to see whether inmates are vaccinated prior to entering but couldnt find that information, Poor sleep has a huge impact on glucose and spikes and also plays a role in maintaining optimal immune functions, Rhonda takes melatonin to help her sleep, 10 mg/day, Regulating circadian rhythm is crucial for sleep, Rhonda makes sure to have bright light exposure in the morning (e.g., opening curtains, walking outside), and changes the lighting in the house in the evening to red lights, 70% of US population has insufficient Vitamin D levels; 28% are deficient, Body can generate naturally when exposed to sun daily, Obese people in US are also more likely to be vitamin D deficient, Genetic polymorphisms: people that have variations in genes that cause them to have less vitamin D, These people are more likely to die from respiratory infection, African Americans in the US are 28x more deficient in vitamin D than Caucasians, A recent study that looked at COVID-19 patients observed an inverse relationship between vitamin D levels and COVID-19 symptoms: the lower the vitamin D levels, the higher the severity of COVID-19, In Indonesia almost all patients that died from COVID-19 were vitamin D deficient, Melanin blocks ability to produce Vitamin D, In the US and Europe, African Americans and black people are more likely to die from COVID-19, Even when adjusting for SES and lifestyle factors, this was still true so something else must be happening, Tolerable upper intake is 4000 IUs per day but its best to get vitamin D blood test to measure levels, There are clinical studies exploring the role of vitamin D but not many in the US, Rhonda wants to see nurses and first responders take vitamin D to see the role in prevention but those studies are not being done, Joe uses the sauna 7 days/week, 180-degrees for 25 min, Rhonda uses the sauna 5 days/week, 180-degrees for 25 min, Heart rate variability improves, blood pressure goes down, cardiovascular health improves, all-cause mortality decreases, Sauna use also improves immune system and makes you more resilient against infection, Brain-derived neurotropic factors (BDNF) increases with exercise and heat stress (sauna), The positive benefits of physical activity on the cardiovascular system were enhanced when sauna was added, Sauna use increases heat shock proteins which prevent muscle atrophy, neurodegenerative genes, and have anti-depressant effects, People who sat in 160-degree sauna for 30 minutes had a 60% increase in heat shock protein compared to baseline, Large Harvard study being done to assess whether hot yoga increases heat shock protein, Heat shock protein have antiviral activity against influenza A, Regular sauna is heating ambient air which in turn raises core body temperature, Infrared saunas are directly heating body without heating the ambient air for example, in a heating tent or blanket, We know more about the effects of dry sauna, For people who dont have access to sauna, a hot bath is a good modality for heat shock protein, Studies being done to assess whether sauna can have anti-depressant effect on depressed patients, Saunas could also provide an avenue for giving sedentary and disabled people the benefits of physical activity without exercising, Ice baths and cold showers can be comparable to cryotherapy but you have to stay in the cold water longer, Cold shock protein hasnt really been measured in humans, instead whats measured is norepinephrine which has been shown to increase, Cold shock protein and hot shock protein have been shown to improve mood as well, The pharmacokinetics of vitamin C are very different in oral vs IV consumption, Oral vitamin C is good for immune function, etc. It is used as a like if you're eating it, you know, I think it could cause like like you're with a tall kind of thing affect where it's like too much GI distress. But I want to know how I really feel about this and how I really feel about this is very different now versus the way it was in March, because in March I was concerned and I was like, Jesus Christ, this could be terrible. And so they have like the day I won, it was not Coed Day. I loved it. That's going to be coming soon. W what is, what is the top of this. Like, it just feels really it's a nice shock. It's an annual day dedicated to Trager that encourages our nation to grill and celebrate all things Trager and the Trager day sale is May 15th through 17th. That's Louis right there. So usually I just kind of scream and wake up and like, I'm like, look, I think someone's going to get me, you know, melatonin totally, totally stopped. Thanks buddy. This was the worst that's ever happened to me. How other health factors, you know, and but there was a big study just released not long ago from from like the National Office of Statistics in Britain or something like that. And that's then raising our core body temperature through that mechanism. And they found with influenza, I forgot which a or something. The bottom line is on honesty, that's intravenous. I forgot the name of the test, but yeah, that's that's the test. It's questions interesting because it's Zingana for it's also been identified to have activity against Sajko one antiviral activity against Sajko, one doesn't nootropic properties as well. He's you know, some of your friends are a little eccentric, right? Look at this, athletics, badminton, singles, throwing a baseball, softball, BMX riding, canoeing, singles crabbing. I think social distancing makes sense. And then they measured in multiple years as they became children and the mothers chewing it, chewing the gum. I know you do. I think 50 degree Fahrenheit water or something like that, I don't remember the exact time, but but it is comparable, but you have to stay in a longer duration. There's your your your genetics. So it's one of the reasons why, like, you know, shift shift workers like A really are prone to Type two diabetes. Yeah. Absolutely. And that's that's what, you know, is happening at the hospital and in New Jersey. People are starving. Just the conversations you have with people that are into releasing toxins. No, it's the popcorn. You know, after doing just so much, of course, the past couple of months, I've been nothing but like reading about the immune system and trying to understand, of course, this new virus, sars-cov-2. So yeah, if I'm in a rush and I'm like, oh my God, I'm here, I got to you know, I got things to do. And what's interesting is that there's been tons of like genetic studies done on like, you know, identical twins and they're followed over time. It is almost obvious. Quercetin . Sign up for an annual subscription and receive an additional 15% discount. So, like, what if there's, I don't know, the CMB, you know, percentage there, but what if the coronaviruses are going around there? Well, the IV is it's totally IBS, totally different. What works. They're not just making whiskey. I don't. You know, there's no data showing that. Top Moments. And so like I mean, you're breathing like it's like burning you. I visited Finland. Do so I that. And I think that doing the sauna is making you more resilient against against infection like there. She has dedicated her research career to finding proactive and preventive solutions to aging and longevity. Hiking trails and paths allowing distancing horsetrading singles jogging and running. It's insane. Yeah, right. You strap your ankles into it and you hang from the waist and it just all that's it right there. Good. And, you know now. Trager and the Trager Day Sale goes from May, May 15th, which is tomorrow to well, you'll get this today, May 15th, May 17, 20 percent off all Rob's sauces and liners. Sign up for an annual subscription and receive an additional 15% discount. That's right. And I think vitamin D is going to potentially play a role there. It works. That would be because that would be like. So that's that's about 10 grams. So so then 200 milligrams. But now it seems like as times gone on and people getting more frustrated and more desperate and more depressed because they're locked up, it seems like it's ramped up. But that basically prevents them from having this new mutant that's predominant in Europe and also in New York, in North America in general. I would do I would do my yoga or my ballet and then I would run. You think so? And in fact, because the zinc is bound to fight weight, it's less bioavailable. Vitamin D deficiency is what makes it worse. But llamas seem to be here. So you hook yourself into it and you just lift your back everything that I'm scared to do. You should when they start to go there, I'm like, you should have a hard time and you should judge. So I have like all the apps and stuff and most of the time like and I turn my my my iPhone screen is like down and they have the black background and all that. Do you, do you do like electrolyte replenishment. You know, it's important. Really high profile releases of these horrible people that should be in jail probably forever, and they're releasing them. So it's not like a hard core quantitative biomarker which is so badly needed. And I think it's vitamin D. I think that, you know, so, you know, the vitamin D, like it hasn't looked vitamin E. I'm not saying that vitamin D is going to prevent you from getting covid-19 or it's a treatment, although I am involved in a clinical study where we're going to be testing a very small open arm study we can talk about. Once the active form is achieved, it travels all over the body while filling a role for several diverse functions including: Building muscles and bones Absolutely. And that's also that's also known, you know, so I think all those things and then the sleep. But it's also good to know that, oh, wait, if I take a higher dose, there is an effect. It's been shown to people. You're you're getting them and they kind of just move around just to feel like their nose just moving around. Yeah. And the sauna, but but I need to be better about resistance training for sure. Rhonda has mentioned the Nordic Naturals brand on . So we've been doing like. Yeah. There's a formula and in a lot of the studies and coming out of Finland, many of the people there are using are doing the the humid stuff on us as well. Did, you know, like between 50 to 80 percent of the U.S. population has it like at least by the time they're like an adult has it permanently or so it's a it's a herpes virus. I can't say enough good things about this grill. And they were there. I'll get you a trainer. And at that point I, I was like looking through everything on my toiletries and everything, like, what do I have to get rid of what's in there that could be harmful and smells like fluoride like in my toothpaste. Like, children are really good at that. This this is not cold at all. Yeah, for Jamie, can you pull up filmi fitness and there's a vitamin C topic page so that we I can answer that question better because there's just there's a graph if you just like scroll to the graph, there's like all this is on your website, which tell everybody I found my fitness dotcom vitamin C or episode page of the podcast. Wow. And from what I understand, that this is a vulnerable virus in terms of the temperature that it can survive in. So it's thought, oh, well, the same we're seeing the same, you know, pattern where people with Type O are protected from sars-cov-2 possibly. So here's my. What does that thing called Jimmy belt squat belt squat. I didn't know anything about that. Yeah. It really is like like that's another thing. So you can see 10 grams is like in 10 grams is 10000 milligrams. It's a lot. All right. And and so I have a knowledge base here. Nonsense and negative garbage. Yeah. It gets gets grosser meditation. Mine's mine's right here. You'll find it. What factor do you think, like when we're talking about Centage before one of the things this is a respiratory disease and this is something where you're breathing in these particles. You were going to be totally shocked. It's cool. So like in combination with some of this other stuff, like from days of yore, which is, you know, it's not like a silver bullet, but it seems like it's also promising, promising probably with a combination of other other factors as well. And you know, the effects on babies. Please do. Dr. Patrick recommends people get their vitamin D levels tested before deciding on the own optimal dose, but that she recommends aiming for vitamin D test results in the 40-60 ng/mL range. The RDA needs to be like almost three times as high for them. Like it's so great for the mind. They're like they're like directly heating. That means everything is probably fine because it's such an enormous part of your body. But it's like small quantities and like do you ever get concerned from the high volume of leafy greens you have conservative oxygenates or getting kidney stones or anything along those lines? I've seen a guy who wears one of those, but he's diabetic.
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